| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 09-12-25 15:30 | Kairat Almaty | Olympiakos Pireu | 0:1 |
| 09-12-25 17:45 | FC Bayern Munique | Sporting | 3:1 |
| 09-12-25 20:00 | AS Mónaco | Galatasaray Istambul | 1:0 |
| 09-12-25 20:00 | FC Barcelona | Eintracht Frankfurt | 2:1 |
| 09-12-25 20:00 | PSV Eindhoven | Atlético Madrid | 2:3 |
| 09-12-25 20:00 | Atalanta Bergamo | FC Chelsea | 2:1 |
| 09-12-25 20:00 | Tottenham Hotspurs | Slavia Praga | 3:0 |
| 09-12-25 20:00 | Royale Union Saint-Gilloise | Olympique Marselha | 2:3 |
| 09-12-25 20:00 | Inter Milão | FC Liverpool | 0:1 |
| 10-12-25 17:45 | FC Villarreal | FC Copenhaga | 2:3 |
| 10-12-25 17:45 | Qarabag | Ajax Amsterdão | 2:4 |
| 10-12-25 20:00 | Athletic Bilbao | Paris St. Germain | 0:0 |
| 10-12-25 20:00 | Bayer 04 Leverkusen | Newcastle United | 2:2 |
| 10-12-25 20:00 | Borussia Dortmund | FK Bodö/Glimt | 2:2 |
| 10-12-25 20:00 | FC Brugges | FC Arsenal | 0:3 |
| 10-12-25 20:00 | Juventus Turim | Pafos FC | 2:0 |
| 10-12-25 20:00 | Real Madrid | Manchester City | 1:2 |
| 10-12-25 20:00 | Benfica | SSC Nápoles | 2:0 |